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| Jr. Activist Join Date: Sep 2003
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| Pot-like Drugs Worsened Seizures in Lab Rats Sheryl Ubelacker | Canadian Press | August 10, 2004 TORONTO (CP) - Some people who use marijuana to try to control their epilepsy could actually risk making their seizures worse - if research showing the drug's effects on laboratory rats is any indication. Bellatrix; I can't believe this kind of garbage passes for science. These so called "scientists" actually used a synthetic copy of THC, NOT the actual stuff. This kind of manipulation is so cheap it makes me ill. Scientists at the University of Saskatchewan have found that although a synthetic version of pot's active ingredient can suppress grand-mal seizures in lab rats, in some cases it may intensify the most common cause of convulsions, those which originate in the front of the brain. Some people who can't tolerate the side-effects associated with standard medications to treat epilepsy - from headaches and nausea to drowsiness and cognitive dysfunction - turn to marijuana or synthetic forms of the psychoactive ingredient in cannabis, THC, to reduce the severity of seizures. Bellatrix; yes, this is what we've been saying the whole time - REAL marijuana is SAFER than the sythetic stuff! And here's the science to prove it! Whoo hoo! While previous studies had identified no adverse effects, new research led by Dr. Michael Corcoran at the University of Saskatchewan unexpectedly found that the pot compound can actually cause seizures in laboratory rats. "What we found was contrary to our expectation in that although after a single injection there could be a suppression of seizure, when we gave the drug more than once to the rats over a period of days, their seizures actually got worse," Corcoran, a professor in the department of anatomy and cell biology, said Tuesday from Saskatoon. Researchers are able to simulate epilepsy in rats through a process called kindling, in which tiny bursts of low-voltage current are administered over time. With repetition, the electrical discharge spreads from brain cell to brain cell, eventually creating a kind of firestorm of neural activity that resembles what occurs in human epilepsy. Bellatrix; what?? That's disgusting! And this is considered a reasonable model for a human being with epilepsy? Gee, maybe getting electrucuted repeatedly had something to do with the degeneration of these animals? No, it was the evil marijuana-like compound that killed them! Corcoran's team found that kindling gets worse when rats are injected with high doses of the marijuana-like drug. The doses were high enough that the rats also ended up stoned: some were immobile, had changes in muscle tone and their ability to walk a beam - a measure of intoxication - was affected, he said. The long-term goal of such research is to figure out how a certain drug might work in humans, said Corcoran, who has been working in epilepsy research for about 30 years. "Ultimately, it's always an empirical question," he said. "Do the effects of a drug in a rat predict the effect of that drug in a human being? For drugs that are useful in treating epilepsy, that's generally been the case." Those effects also depend on the type of seizure, he said. With those that originate in the brain stem, located between the brain and the spinal cord, cannabis-like compounds have been found to suppress convulsions. But "what our work suggests is that seizures that originate in the forebrain, particularly in the temporal lobe, probably are not the best candidate type of epileptic seizures to be treating with marijuana-like drugs." While it's difficult to calculate the human equivalent of the doses given to the rats - especially since street pot and reportedly even government-sanctioned medicinal marijuana can vary in strength from batch to batch - Corcoran said the study's findings should possibly give pause to some people using cannabis for epilepsy. Bellatrix; what about marijuana-like compounds? Can we use those to treat epilepsy? "If I were a clinician and I had the option of using marijuana to treat seizures, I'd want to make very sure what kind of seizure type the particular patient was displaying, because some seizures might benefit from these drugs, but others might get worse," he said. And for those with epilepsy who want to use weed to self-medicate? "I would say, 'Make sure you don't take whopping big doses and be sensitive to the kind of epilepsy you have.' " Bellatrix; thanks for the advice, Doc. I couldn't find out very much about our Doc Corcoran; but I would be very interested to see who funded this study. He's been well trained by someone. |
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| Pot-like? No such thing, except, of course, for Cannabis ~ It's the Real Thing The Original, and still the best. Ask for it by name; accept no substitutes. It's a Natural! *some assembly required; see dealer for details
__________________ Alien Space Signal There's no money for your issue so long as we're squandering $50 billion a year on the DrugWar. Ben Masel Fear became the ultimate tool of this government - V. |
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RE Funding: With funding from the Canadian Institutes of Health Research and the Saskatchewan Health Research Foundation (SHRF), group leader Michael Corcoran is using rats to study the effects of a new generation of cannabinoid drugs I, for one, am impressed with ANY researcher who is investigating the clinical use of marijuana and this guy appears to have an open mind about it. From: Canada Institute of Health Research: Quote:
In my opinion Corcoran should be lauded not lambasted | ||
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| "Bellatrix; I can't believe this kind of garbage passes for science. These so called "scientists" actually used a synthetic copy of THC, NOT the actual stuff. This kind of manipulation is so cheap it makes me ill." I'm not positive but, I think they use a synthetic copy of THC so they can be sure they are using the EXACT same amount of THC every single time. Otherwise this wouldn't be a scientific study at all. Also maybe the synthetic copy is what they plan to actually use in a pill or medicine one day, then it would be useless to use real THC in the experiment. This is just a study IMHO. |
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| Looks like Canadian scientists have prooven that fake pot is not effective against fake epilepsy, eh! Years ago, in a study also involving rats, US scientists "prooved" that saccharine causes cancer. The rats were given daily doses equal to a human consuming 10+ cases of diet soda per day for ten or more years. As far as I know that study did not invokve drilling holes into the skulls of the rats tho... |
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| More scientists getting sick pleasure from abusing animals in the name of "science"... maybe their experiments would hold SOME value if they used MARIJUANA, and not that chemically concocted bull**** they decided to use. In my opinion they are idiots and their studies are useless, except maybe for the few people in the world who drill holes in their heads and give themselves small electrical shocks for long periods of time, now they can rest assured that THC like medication won't make their "seizures" any better! woohoo what a medical breakthrough. |
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