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Old 02-05-2004, 12:53 AM   #1
Higher Logic
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Default Marijuana & IBS, Crohn's, MS

I've had IBS symptons since I was in the 9th grade. When I started smoking marijuana, the effects went away. Here is an article I found on the subject:

Quote:
Although the use of cannabinoids as antiemetics (anti-nausea) is well-established, with Dronabinol available to stimulate appetite and counter effects of cancer chemotherapy, the effect of cannabinoids on disorders of the gut has not been extensively studied. However the current state of knowledge of the biochemistry of cannabinoids is increasing at an exponential rate and, with discoveries of cannabinoid receptors in unexpected areas of the body, new potential research/treatment avenues are appearing at an increasing rate.

Grinspoon reports anecdotal use of cannabis to control bowel movements in multiple sclerosis, and relief from the symptoms of Crohn"s disease. Mikuriya records irritable bowel syndrome, as well as other inflammatory gastrointestinal conditions (principally among AIDS patients), as one of a wide variety of conditions for which cannabis has been prescribed or recommended for therapeutic use in California. There are no clinical trials currently published, and consequently use for the treatment of irritable bowel syndrome would represent at best an experimental therapy.

However, there does appear to be some scientific support for any claimed therapeutic benefits from the research literature concerning the actions and metabolism of cannabinoids and cannabinoid receptors. The wall of the intestine is composed of a type of muscle known as "smooth muscle", also found lining the walls of arteries and in other involuntary functions.

Rosell et al first demonstrated that cannabinoids inhibit contractions of the small intestine in the rat. Pertwee et al established the presence of cannabinoid (CB1) receptors within the guinea-pig intestine and Kazuhisa et al established the presence of enzymes break down anandamide (the endogenous cannabinoid CB1-agonist) within the small intestine. The smooth muscle-relaxant properties of cannabinoids are so well established that preparations of guinea-pig intestine are routinely used as an in vitro screening tool to test the potency and function of novel cannabinoids.

Shook & Burks found that THC reduced the frequency of intestinal contractions, and reduced the flow of food in the small intestine, without altering basal tone, and concluded that

"...delta 9-THC, delta 9,11-THC, cannabinol and nabilone (but not cannabidiol) exert an inhibitory effect on GI transit and motility in rats".

Cadas et al reported that a gut enzyme (vasoactive intestinal peptide) may regulate the precursor chemical to anandamide (which activates cannabinoid CB1 receptors) and N-palmitoylethanolamine (which activates a CB2-like receptor subtype), suggesting that endogenous cannabinoids may play a role in regulating the activity of the gut.

We are not aware of any controlled studies of medical use of cannabis in the treatment of irritable bowel syndrome, there appears to be sufficient evidence of the potential efficacy of cannabis in reducing intestinal spasms to merit further research into this and related indications. Any symptomatic relief obtained from smoking cannabis would occur far more rapidly than with oral preparations.
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Old 02-06-2004, 09:09 AM   #2
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You just got yourself a Sticky!

Great work...

have a cookie

Hugz,

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Old 03-05-2004, 01:48 AM   #3
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Cool Relief for MS symptoms.

Quote:
Originally Posted by Red
I've had IBS symptons since I was in the 9th grade. When I started smoking marijuana, the effects went away. Here is an article I found on the subject:
Harpman-I've been struggling with Multiple Sclerosis for quite awhile. I'm on Vicodin for severe pain, Neurontin & Zanaflex for spasms and tremors. I've been told from alot of my friends with MS that smoking pot has really helped them. I'm desperate for some relief as I'm also on Chemotherapy and it's all almost unbearable. Can any of you out there give me any advice or suggestions about how to acquire and the legal issues I will encounter? This is my first time posting so if I've done anything wrong please let me know. Thanks, Barry
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Old 03-05-2004, 02:54 AM   #4
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Regrettably Florida is NOT a Med MJ state...but it has a strong activist community working towards it.

Your best bet for information on medical cannabis would be to contact the activist community and specifically Jodi James of the Florida Cannabis Action Network FLCAN LINK

There are various ways to try cannabis -- either through friends who use it, or you may wish to travel to a country where it is less criminalized than hours,for example Jamaica, and try it there.

If it proves to be effective for you -- and many MS patients swear by it including Montel Williams (who went public with his use in his recent book) -- you should consider growing it yourself in your home, thereby both cutting out the need for involvement with the black market and supplying yousrself with a high consistant quality of cannabis as medication.

Hugz,

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Old 03-12-2004, 12:45 AM   #5
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Thanks for the info Red! I've been lactose intolerant since I was a child and was diagnosed with IBS in '98. Having both I'm not sure when the IBS really started. I was originally prescribed Modulon(I think that's what it was called) but I didn't see the point of taking pills every day when I didn't have IBS pain everyday, so after about 6 months, I quit taking them. I think it was around that time that I started using marijuana regularly for insomnia and now a few years later I realize that all this time marijuana has been helping my IBS too and I didn't realize it. One of the major causes of IBS is stress, or at least it makes it worse, and I thought marijuana was helping by relieving my stress. Now I find out here that it is more than that. I may have cannabinoid receptors in my bowel? I wonder how else marijuana is helping me that I'm not aware of because I smoke it daily. I'm not about to quit and find out the hard way, I think I'll just keep reading here and see what else I can learn.
Thanks for sharing this Red.
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Old 03-12-2004, 11:05 AM   #6
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I hear ya on the taking pills everyday. They have nothing really available for IBS besides things like Immodium AD (there are prescriptions available, but Lord knows what those do to you). Eventually I just became immune to I-AD, and I didn't realize either that my symptons were gone until I started researching cannabis and IBS. A holistic doctor and modern medicine couldn't fix anything, but a natural, God-given plant sure did the trick.

My grandpa suffers from Chron's, I wish he would just smoke some herb with me He's extremely Christian though (then again, if Christians read the Bible they would see it's OK to seek relief in what God has provided on Earth), the thought of "pot" to him wouldn't settle well.
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Old 04-02-2004, 03:19 PM   #7
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Unhappy

Hi,

I just found this forum.

i have crohns. Sorry, but it hasnt been going well lately. That gut motility thing was interesting.

I just dont understand why............why? why me? why crohn's? why ca't they just get off it and let us smoke in peace!

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Old 05-04-2004, 10:43 PM   #8
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Nice thread. I was diagnoised with Ulcerative Colitis when I was 11. What a horrible experience this was. Couldn't go anywhere without locating a bathroom first. I didn't smoke weed until I was 24. Didn't do it for medical reasons, just thought it was time to give the stuff a try. 4 years later, that's 4 years without prescriptions, enima's, imodium, ect., I never worry about where the bathroom is, should I leave the house, or having my legs go numb from sitting on the toilet 20 times a day. The only symptom I still have is sitting on the toilet whenever I read, even If I don't have to go. I can't believe this wonderful plant is still illegal. Peace.
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Old 05-05-2004, 10:11 PM   #9
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There's is a valid reason for not legalizing marijuana, can anyone guess it. Nope I not going to say cuz it's dangerous, because it's not. Just the fact that american corporatons don't like the idea of having a single cheply grown plant solve everyone's problems. They'd rather have you use their drugs, all made synthetically in a chem lab, at markup prices. who doesn't want to line their pockets with gold. Let's keep educating people on the positive values of marijuana, but don't go around with the attitude that marijuana is completely harmless, lest you wish to get chewed out by a chemistry profesor. Marijuana does have a slight downside, and that also must be expressed; however, the facts are that marijuana has an overwhelming number of positive uses. Use all this to your advantage, teach the population. This is a great site for educating those already wanting legalization, but now we need to public, armed with our swords of truth (clinacally backed of course) and prove to the world that we wnat pot, pot is good for society and would greatly stimulate the economy. By the way I prefer teh term cannabis to marijuana considering cannabis was illegalized under the alias 'marijuana.'

Peace to all, smoke a Jay,or blunt and keep up the good work,
Stonerbob
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Old 05-07-2004, 11:14 PM   #10
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You are correct, Bob, cannabis is not completely harmless. Neither is the air that we breathe or the water that we drink. The key words when discussing cannabis safety are harm reduction and relative safety.

More folks have died from ingesting excessive water than cannabis. Too much water upsets electrolytes, causing scrambled electrical signals and eventual death from organ failure. Most often seen in people with unnatural compulsions to drink water or occasionally in extreme sports.

That would be a case of relative safety. Relative to the addictive and potentially damaging or even fatal effects of opiates, cannabis is very safe. Relative to the number of folks that suffer severe liver damage or even death from aspirin, cannabis is very safe. Etc etc etc.

Using cannabis to reduce the amounts of opiates needed to achieve the same amount of pain relief is a case of harm reduction. In MS, my friend Cheryl used to receive IV solumedrol (potent steroid) for 3 consecutive days, then be rapidly withdrawn from it (normally a dangerous no-no in steroid treatments) to try and shock her immune system. This used to occur every 2 to 4 months for her. Since undertaking cannabis therapy with her neurologist, she now goes from 5 to 9 months between such treatments. That is harm reduction. Basically, you substitute a less harmful substance that provides relief for a more harmful one, or at least to cut the intake of the harmful treatment.

Overzealousness and stating only the good of cannabis is, in my opinion, at least as harmful to the cause as the propaganda put out by the "other side". To achieve respect and trust, truthfulness, even when slightly negative, is very very important. Nearly any substance on earth has the potential to cause harm, you just need to be factual and show how relatively safe cannabis truly is. I have found this especially true when dealing with doctors and such.

Best all,
MM
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