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EveryTimeIDie

Now, I've always heard of people not getting high the first time they smoked, but I always assumed this was because the person didn't know how to inhale properly. But recently, I had the opportunity of smoking with someone who had been clean for an entire year. We smoked 2 phat bowls of some decent stuff, and I got pretty damn stoned. He, however, didn't feel a damn thing. He definetly inhaled and had taken some incredibly big hits. I was thinking this might have happened because he hadn't smoked for a full year and had reverted back to the state where you can't get high the first time you smoke. If this is true, I would like to know what causes someone to be "un-stoneable" like this...?

 

DiabloPotHead

I think it's the neuron connections in your brain. In science we were taught that your brain is constantly making new neuron connections and adapting, so, it would make sense that your brain needs to do some rewiring before you can get high.

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Phyxius

Except that cannabinoid receptors in our brain are present from birth. Our bodies are built to be able to get high. Our bodies create small amounts of THC naturally. There's a theory that our bodies' natural THC is our body's natural defense against schizophrenia. As for the original question, I have no idea. I just don't agree with that explanation. But I would like to know the answer - myself, I didnt get high until the 7th time, and it wasnt because I wasnt doing it right.

Insomniac

I got high the first time, so did everyone I know.

I always thought it was because they didn't inhale properly, too.
Maybe it was psychological, you know?

Phyxius

And I really dont get this "they didnt inhale properly" thing. All you have to do is take a deep breath (or not so deep, whatever) of smoke. The only way that would be the wrong way is if you just hold the smoke in your mouth and dont actually breathe it in, but you'd know if that's what you were doing.

 

TNTMagicHerb

The reason you dont get stoned the first time that you smoke is because you dont know what to expect or even what being high is. Simply your mind thinks about it so much and trys to feel something that it almost overpowers the high. When you ask them if they are high they say no but show all the signs red eyes, rambling talk, dry mouth, and giddy. They just dont know yet that this is being HIGH! Now as far as the guy who hadnt smoked in a while... hes a freak of nature.

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didorusso

if they say no it's no! To me it is related to brain receptors for THC, but I am not sure about the mechanism. Maybe, receptors are initially scarce and become more abundant when the first THC stimulations occur.

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teufelfisch

I agree, I think it's just that they don't realize they're high.

I didn't get high the first time, but all we smoked was some resin left in the bottom of their bowl -- not enough to get anyone high. The second time, I got so stoned I thought everything was 2-D!!

As for your friend, it's gotta be something psychological. I believe tolerance is psychological to some extent, and through this, a person can build up a tolerance that never goes away. For example, no matter how much I smoke, I can never get as stoned as I was the first five times, even after quitting for several weeks.

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didorusso

THC receptors mediate tolerance. In this case, receptors decrease from the membrane of brain cells, probably because once bound to THC they become internalized. You'll become tolerant for a while (few days to 1 week) until newly synthesized or recycled receptors are put back in the membrane.

Said that, me too never get stoned as the first times

Cassius

You wouldn't know it if you were new to smoking of any kind. Many people who first start smoking cigarettes, only pull it into their mouth and then let it go, and never really inhale. So, if you have a new weed smoker who has never smoked cigarettes either, then it's not uncommon for them to not completely inhale.

Whereas a new (to weed) smoker who HAS smoked cigarettes before, will already know how to inhale, and probably won't have a problem.

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