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THC4life

Well the following msg is more geared toward any docs or all you weed experts out there...

Well I've been wondering...you know how we all come "down" from being high? Well what exactly causes this? I know that the actual THC chemical is fat soluble (which is why it stays in ur system for so long) but why is it that your high goes down?

When you compare it to alcohol (I know it's off-topic but I'm just making a reference) the reason you lose your "drunkness" is cuz obviously your liver breaks it down and as many of you probably have experienced first hand, this takes between 1-10+ hours, depending on how many drinks you've had. Also, if you drink lots of water, you can sober up quicker too...(alcohol is water soluble) On top of this, once the alcohol gets broken down (I forgot into which other molecule), it only stays in your system for the next roughly, 12-24 hours.

So bearing this in mind, THC quite obviously works a lot differently than alcohol. You can drink gallons, upon gallons of fluids and you'll still be high. You eat a large meal and according to the way you are, it kills your buzz shortly after. So yea, it might have to do with the fats in the food and what not but that still doesn't explain why if you smoke a joint today, ur high wears off after a few hours and even tho the THC is still in ur system for the next 2 - 4 weeks, you're not high during that time period. Also, I read somewhere that your liver doesn't break down THC as it does alcohol, instead of being broken down, it just gets absorbed by your fat cells.

So can someone please shed some light into this confusing, yet highly satisfying chemical?

__________________
Pick it, pack it, fire it up, come aloooong
and take hits from the boooong....

 

sirsmokealot420

thc is not exactally what they test for in urine. they look for a certain metabolite that comes from the thc that was in your system.

Mamabudz

The metabolism of cannabis is exceedingly complex and incompletely understood.

There are over 60 cannabinoid compounds in cannabis currently isolated. Each of the main ones studied thus far are often broken down into many metabolites and several different routes of metabolism.

FOr example the important initial step in the metabolism of the main psychoactive constituent, D9-tetrahydrocannabinol (or "THC"), is catalysed by cytochrome p450 2C9, other cannabinoids have other catalysts.

Catalysts can be enzymes (proteins) or other bio-chemical acids or bases.

These too are still unknown territory.

Unfortuneately the USA government disallowed research of Cannabis in the mid 1970's and that embargo continued until this year.

How much firther ahead would we be in the understanding of this miracle plant if the US had not been so damned parochial in its thinking

...better all have a cookie

EeJay

I've never heard about what you said about eating, and i'm no expert, but I don't think it works that way.

A slightly educated guess from me says after a period of time, the THC and other cannabinoids simply detatch from cannabinoid receptors in your brain. My guess is once the cannabinoids get weak, is when they detatch.

__________________
Experience is an honest teacher.

THC4life

Well about the whole food thing, I was just saying that cuz it almost ALWAYS happens to me. I could be buzzing nicely, I get the munchies, eat a large meal, and about 20 min later, my buzz starts going down really fast....But when I eat something light but filling (ice cream works great) my buzz doesn't go away.

Hmm....I guess it's just how my metabolism is?

 

EeJay

Well it could very well be like you say, I was just giving my opinion. I actually tend to believe experiences before any theories. I guess we don't find out for sure just yet.

dedbr

of a "buzz" is actually an allergic reaction.You are actually experiencing a poison reaction in your body.

All buzzes are a poison reaction,meaning that this feeling is actually your body's reaction to the toxin's that are being processed by the brain and other organ's.Yeah,that's right,poisin.

I didn't like it either when I found out the real feeling is bad for me,but a buzz is nothing more that a way to hurt your self by ingesting the toxin's that are in the smoke.I bet if you inhaled the smoke from a house fire,the first reaction would be a woosy,or "high" feeling,then ,since your body couldn't process the toxin's quick enough,the next reaction would be to pass out and then die.

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Mamabudz

Dedbr....

...got any PROOF to back up your "marijuana is poisoning the body" theory????

That might be the case with alchohol poisoning...and in fact it is...

But I haven't come across your theory in any of my reading.

Gotta back up those theories with PROOFS my friend....

...take a cookie and get back to me when you can

dedbr

as far as I can tell from my reading's,all so called "High" or "Buzz "
effect's are a poison reaction from ingestion of any substance not natural to the human form.

In my day's at college for counseling and substance abuse,we even learned that people that are lactose intolerant can have the so called "poison effective response" to milk or cheese product's.While poison reaction is perhap's not the best wording for the effect recieved from marijuana ingestion,it is widely accepted among my peer group as the correct description.

This effect recieved from marijuana is of course non life threatening in it's current form,so like I said,poison response is perhap's too threatening for this drug,but it is non the less a drug,and the bodies response is physically noted as the same.

A few times I have seen newbies smoke real strong weed and the bodies response is to vomit,which is a common physical response to a poisoness substance ingested into our bodies,I'm sure you agree.

Of course ,in our present world,not enough testing has been done to measure the actual physical effect,but like I said,this is the most accepted way to describe a "High" among people who should know.

Have a snack cake....

Mamabudz

Then definitely cut Marijuana out of that list as humans have endogenous cannabinoids and cannabinoid receptors.

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In my day's at college for counseling and substance abuse,we even learned that people that are lactose intolerant can have the so called "poison effective response" to milk or cheese product's.

That is because they lack the endogenous enzymes necessary to digest milk ~ by the way the effect is stomache cramps and vomiting

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While poison reaction is perhap's not the best wording for the effect recieved from marijuana ingestion,

Actually, it is the WRONG word...

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it is widely accepted among my peer group as the correct description.

Your peer group who reads your "readings" or your old college peer group from "substance counseling" ?

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This effect recieved from marijuana is of course non life threatening in it's current form,so like I said,poison response is perhap's too threatening for this drug,but it is non the less a drug,and the bodies response is physically noted as the same.

Hogwash dear. Marijuana is non-toxic. Poisons are by definition toxic

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A few times I have seen newbies smoke real strong weed and the bodies response is to vomit,which is a common physical response to a poisoness substance ingested into our bodies,

The vomit response is usually due to:
1...inhalation of smoke triggering a vomit reaction
2....swallowing smoke triggering a vomit reaction
3... sudden diaphragmatic action in response to smoking causing...vomiting...usually called coughing ti you puke.

What were you doing as a substance abuse counselor watching "newbies" smoke "real strong weed" ???

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I'm sure you agree.

Don't bet on it...and please try to get your facts straight next time.

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Of course ,in our present world,not enough testing has been done to measure the actual physical effect,but like I said,this is the most accepted way to describe a "High" among people who should know.

But not amongst those of us who know better

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Have a snack cake....

Not if it is as half baked as your theory of Marijuana Poisoning but the thought was generous