Temple University Research Indicates THC May Be Beneficial For Organ Transplant Patients

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A new study performed by scientists at Temple University and published in the Journal of Neuroimmune Pharmacology and the National Institute of Health, discovered that that marijuana’s primary psychoactive cannabinoid – THC – can potentially stop organ transplant rejections, claiming; “Cannabinoids are known to have anti-inflammatory and immunomodulatory properties.”

The Temple University research showed the protective nature of THC, particularly when taken in higher doses; “this data supports the potential of this class of compounds (cannabinoids) to be utilized as therapies to prolong graft survival in transplant patients.”

Abstract

Cannabinoids are known to have anti-inflammatory and immunomodulatory properties. Cannabinoid receptor 2 (CB2) is expressed mainly on leukocytes and is the receptor implicated in mediating many of the effects of cannabinoids on immune processes. This study tested the capacity of Δ9-tetrahydrocannabinol (Δ9-THC) and of two CB2-selective agonists to inhibit the murine Mixed Lymphocyte Reaction (MLR), an in vitro correlate of graft rejection following skin and organ transplantation. Both CB2-selective agonists and Δ9-THC significantly suppressed the MLR in a dose dependent fashion. The inhibition was via CB2, as suppression could be blocked by pretreatment with a CB2-selective antagonist, but not by a CB1 antagonist, and none of the compounds suppressed the MLR when splenocytes from CB2 deficient mice were used. The CB2 agonists were shown to act directly on T-cells, as exposure of CD3+ cells to these compounds completely inhibited their action in a reconstituted MLR. Further, the CB2-selective agonists completely inhibited proliferation of purified T-cells activated by anti-CD3 and anti-CD28 antibodies. T-cell function was decreased by the CB2 agonists, as an ELISA of MLR culture supernatants revealed IL-2 release was significantly decreased in the cannabinoid treated cells. Together, these data support the potential of this class of compounds as useful therapies to prolong graft survival in transplant patients.

Source:

[youtube http://www.youtube.com/watch?v=rk-YgQu0lF8]

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Born in Long Beach, raised on the central coast: I surf, dab, burn, and blog – though not necessarily in that order. I'm a husband, a father and a lifelong consumer of connoisseur grade weed. I don't drink alcohol or consume any other "drugs." I consider myself to be living proof that weed is not a gateway drug. If it were, I'd be in some serious trouble. Instead, as a 50-year-old ex-realtor that has been smoking weed for nearly 80% of my life (just did the math) ... I can only say, marijuana is safer than prescription pills or alcohol could ever hope to be for calming what stirs the savage beast.

4 Comments

  1. Pingback: Temple University Research Indicates THC May Be Beneficial For Organ Transplant Patients | 420 News Wire

  2. Pingback: Temple University Research Indicates THC May Be Beneficial For Organ Transplant Patients | Gazelle

  3. Pingback: Temple University Research Indicates THC May Be Beneficial For Organ Transplant Patients | ClairePeetz.Com BlogClairePeetz.Com Blog

  4. And hospitals have been kicking people off of transplant waiting lists if they use cannabis. Sounds like cannabis is exactly what people waiting for transplants should be using!
    When you look for the medical effects of cannabis, not just the bad effects, which they’ve found very little of, you discover great things!

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