Delta(9)-THC and Tourette's Syndrome

Discussion in 'Medicinal Marijuana' started by FreudPhilly, Mar 10, 2003.

  1. FreudPhilly FreudPhilly

    • New Member
    • Since: Nov 16, 2002
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    Hot off the press folks! A very controlled study on folks suffering from Tourette's Syndrome. This will be published in a very respected neuropsychological journal.

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    1: Neuropsychopharmacology 2003 Feb;28(2):384-8 Related Articles, Links


    Treatment of Tourette Syndrome with Delta-9-Tetrahydrocannabinol (Delta(9)-THC): No Influence on Neuropsychological Performance.

    Muller-Vahl KR, Prevedel H, Theloe K, Kolbe H, Emrich HM, Schneider U.

    Previous studies provide evidence that marijuana (Cannabis sativa) and delta-9-tetrahydrocannabinol (Delta(9)-THC), the major psychoactive ingredient of marijuana, respectively, are effective in the treatment of tics and behavioral problems in Tourette syndrome (TS). It, therefore, has been speculated that the central cannabinoid receptor system might be involved in TS pathology. However, in healthy marijuana users there is an ongoing debate as to whether the use of cannabis causes acute and/or long-term cognitive deficits. In this randomized double-blind placebo-controlled study, we investigated the effect of a treatment with up to 10 mg Delta(9)-THC over a 6-week period on neuropsychological performance in 24 patients suffering from TS. During medication and immediately as well as 5-6 weeks after withdrawal of Delta(9)-THC treatment, no detrimental effect was seen on learning curve, interference, recall and recognition of word lists, immediate visual memory span, and divided attention. Measuring immediate verbal memory span, we even found a trend towards a significant improvement during and after treatment. Results from this study corroborate previous data suggesting that in patients suffering from TS, treatment with Delta(9)-THC causes neither acute nor long-term cognitive deficits. Larger and longer-duration controlled studies are recommended to provide more information on the adverse effect profile of THC in patients suffering from TS.Neuropsychopharmacology (2003) 28, 384-388. doi:10.1038/sj.npp.1300047
  2. CheebaMonkey CheebaMonkey

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    • Since: Dec 19, 2002
    • Posts: 5,759
    Very cool. I have two friends who have Tourette Syndrome. And they both smoke pot. :)
  3. Nappe Nappe

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    • Since: Jan 13, 2003
    • Posts: 268
    Great news

    This is a large step for marijuana. I do believe

    :thumbsup:
  4. FreudPhilly FreudPhilly

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    • Since: Nov 16, 2002
    • Posts: 482
    It is a HUGE step because we are linking the functional aspect of cannabinoid receptor sites to undesirable neuromotor behavior. I suspect that there will be further studies regarding Parkinson's.

    However, this is just one study-- we need replication to demonstrate anything solid.

    Cheeba, do your TS-afflicted friends seem to notice their tics becoming more reduced when they have had a steady flow of marijuana?
  5. CheebaMonkey CheebaMonkey

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    • Since: Dec 19, 2002
    • Posts: 5,759
    I'll have to ask them just to be sure.
  6. CheebaMonkey CheebaMonkey

    • Sr. Member
    • Since: Dec 19, 2002
    • Posts: 5,759
    Yes, their tics are reduced.

    :)

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