Lamictal/Marijuana Interaction?

Discussion in 'Medicinal Marijuana' started by chiligumbo, Sep 12, 2005.

  1. chiligumbo chiligumbo

    • New Member
    • Since: Sep 12, 2005
    • Posts: 2
    I recently had a very bad experience. I have been smoking on and off for two years and never had anything happen strange. Recently I was put on lamictal, which is used as a mood stabilizer for bipolar disorder and for people with epilepsy. I was on it for about a month. I had been off marijuana for about 6 months. I decided to start smoking again and did so. The bad thing is that on one occasion I went totally out of my mind talking and being paranoid. I kept smoking and started talking and acting psychotically. I was hospitalized and was in a mental institute for two weeks. I would like to know if anyone has had similar experiences while on this drug because I want to know if there was an interaction. Also I wouldn't reccommend smoking while on lamictal.
  2. silverspork silverspork

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    • Since: Oct 20, 2004
    • Posts: 577
    Hasn't happened to me, but I have a friend who was put into a mental institution for about a week. This was in highschool 2 years ago the week of graduation. We went to the casino one night, and blazed up like always. A couple of days later he began talking to my friends and I about reading people's minds. We of course just thought he was kidding. He went on a couple more days saying wierd stuff like that. Then one morning he got up at 6am, and starting walking to his work place (which was about 10 miles away). His father asked what he was doing at 6am, and the guy wouldn't answer. He also got a mysterious nosebleed at that time, and that combined with acting strange, his dad wanted to take him into the hospital .(he was suspicuous of him doing drugs and he actually called me to ask if my friend had been doing anything). He refused to go to the hopsital so his dad called the cops. The cops took him away and he stayed in a jail cell in the station for bout 2 days. During this time he sat in a meditative stance and barked at the cops, and he punched a cop in the face. He was then taken to the hospital, where they suspected he had smoked pcp. I went to visit him and he was totally gone. For 6 days, he was a complete mental case. He wouldn't talk, and had this strange dazed look in his eyes. Just thinking about it creeps the hell out of me. He came in and out of the episode for a few more days, then he was sent home when they deemed him sane.
    He later told me what he was thinking. He said he thought he was jesus and he was going to work at 6am to heal people. He has gone back into the same type of episode twice when smoking. I think he has acute paranoid schizophrenia.
  3. Mellow8 Mellow8

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    • Since: Nov 14, 2005
    • Posts: 2
    I was put on Lamictal for bipolar disorder. This drug had wierd effects on me. Feelings of panic and doom would come upon me out of nowhere. Often this was triggered simply by eating a meal. I had to give up coffee, in fact anything with caffeine, because the resulting anxiety on these was too much to handle. I was pissed! Also, maybe worst of all, I always felt like I wasn't getting enough air through normal breathing. So, I would often take deep breaths, but it didn't help the feeling.
    The few times I smoked weed while on Lamictal, as soon as the weed kicked in, I would get real tired and have to lie down. I would feel tense. Then I'd get the shakes, fairly vigorous, rhythmic trembling of arms, legs, everything. Totally blew the high.
    Everyone's put together different, so pharms affect us in different ways. But I can tell you for sure, that Lamictal is fully capable of overstimulating your nervous system. When I went off of it, all the panic and shortness of breath went away.
    There is a good chance the Lamictal BY ITSELF caused you to become psychotic. In my experience with psychiatric pharms, they are mostly ****. I was on Paxil nearly a month, and Lexapro for only 2 days. Both seemed to block a weed high. Anyone here taking Trileptal? Does it mess up your high?
  4. kelly5966 kelly5966

    • New Member
    • Since: Dec 20, 2005
    • Posts: 2
    Trileptal doesn't interfer with it at all. I was on it for a long time and smoked fairly often and was fine.
    Now i'm on Lamictal instead.
  5. oneluv4boognish oneluv4boognish

    • New Member
    • Since: Nov 13, 2005
    • Posts: 1,271
    never heard of lamictal...does it go by any other name? is it a new drug on the market?
  6. liveerauoy liveerauoy

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    • Since: Jan 25, 2006
    • Posts: 2
    i started taking lamictal for my bipolar d/o a few months ago, and i have had similar problems as mellow8, such as not feeling like im getting enough air. in addition, on new years, we had 3 bongs being passed around... to make a long story short, i got so f*** up that i felt like i was gonna collapse. before the lamictal, i could smoke for hours and not feel a thing, but new years really freaked me out. although this drug has stabilized me, the side effects sure do suck.
  7. Dedbr Dedbr

    • Domestic War Veteran
    • Since: Mar 24, 2001
    • Posts: 21,228
    I also take Lamictal...

    and also a drug called Cymbalta. I am a daily user and have not experienced the symptom's you state. Perhap's your age and caffeine intake would help us to make a comparison?
    I am 49 and no cigarettes, only herb. Overall good health, low cholesteral. No alchohol. No caffeine. :)

    Ded :cool:
    1 people like this.
  8. blowingsmoke blowingsmoke

    • New Member
    • Since: Aug 11, 2006
    • Posts: 2
    the side-effects fucking suck.

    I'm bipolar and a stoner and I was hospitalized almost a year ago because I went crazy similiar to what silverspork's friend did but mine was actually weirder. I don't remember a lot of it though but i was fucking crazy. anyways, so they put me on lamictal after i got off the strong meds i was on at the hospital and so i kept smoking weed because that was my life before i was hospitalized but now it's a lot different. it isn't the same at all but i didnt stop because i just love weed. but every time i smoke now i get so much anxiety and i can't breathe and i can't handle it and i used to be able to smoke so much and nothing bad happened but now its different and sometimes its actually really scares me because i get so fucked up but it isnt a good high like before, it just sucks now. :( so i don't do it as much but i miss it so much because it was my life, i used to be high 24/7 but now i just can't do it anymore and i wish i didnt have to be on lamictal but i can't go off because im afraid somehting bad will happen. i actually became a member just so i could respond to this. so we should talk more.
  9. Dedbr Dedbr

    • Domestic War Veteran
    • Since: Mar 24, 2001
    • Posts: 21,228
    Listen to me, blowingsmoke.....

    I'm not a doctor and I'm not going to pretend to be, OK? :)

    I'm sure glad you joined the boards and I wish it was for a different reason, but I feel for ya, bro. Being on those meds and feeling out of control can be the worst feeling that there is. I don't have any idea what causes it, but I doubt it's the herb, I think it's a combination of the two.

    When I was first put on the Lamictal, it was a small dose. My doctor knows I'm an herb smoker, so he never puts me on a high dose of anything, he always works me into it slowly. Now, like I said, I'm not a doctor, but have you tried that with herb?

    Maybe if you tried just one, tiny hit, you might have an enjoyable experience instead of the mental mayhem your experiencing now. :D That old expression, "A little bit goes a long way", might fit into this, right?

    Also, I know this one might not go over too well, but what about telling your doctor that you used to smoke herb and see what he says? After all, if your taking meds prescribed by him, maybe you should trust him a little bit more and tell him the whole truth.......:cool:

    Oh yeah, and welcome to the site! :wave: We've got a nice place here...enjoy.....


    Some Where In Ded Land..........
    1 people like this.
  10. LOSTinLIMBO LOSTinLIMBO

    • New Member
    • Since: Aug 18, 2006
    • Posts: 2
    What can we do?

    :( I personally feel for everyone on this thread. I was prescribed lamictal by my doctor back in 2003 and have recently stopped taking it for the past 8 months. Within weeks of taking this medicine I began to feel a pain in my front temporal lobes and feel like my blood pressure was higher than it could ever be,(you know the side of you head pounds) ...whenever I smoked weed. To compensate for this pain I would often go out and find a benzodiazapine to counteract pain that I was having. This worked for a while but the pain killing effects eventually diminished. After a fews months of a lamictal hiatus I decided to once again try smoking to see what would happen knowing that all of the lamictal had left my system and just in case I had a bad reaction I also had medication on hand. When I tryed it out again the effects were unbearable and I havent been able to bring myself to smoke again... even with certain medications. I remember being able to chief all day and be nice and relaxed , but it has been downhill from the time I took Lamictal.
  11. Dedbr Dedbr

    • Domestic War Veteran
    • Since: Mar 24, 2001
    • Posts: 21,228
    You guy's....

    have me feeling bad.....I take it with no side effects so far,( knock on wood ) so I hate to hear you guys are having those problems.

    I can only hope things get better for you and you can get stoned again......:wave:


    Some Where In Ded Land.......
  12. elleforbes elleforbes

    • New Member
    • Since: Mar 5, 2007
    • Posts: 10
    bad interaction between lamictal and weed

    I have bipolar and a partial seizure disorder. I just took my first lamictal, 25mg today. My doctor told me to take it ontop of zoloft and I took the pills together. It made me really anxious, short of breath, and unfocused. I smoked some weed hoping it would calm my nerves, and instead I had the complete opposite reaction. It felt like speed x10. I thought I was going to have a seizure, or a heart attack. I thought I was going to die. I was shaking uncontrollably, extremely paranoia, cold and sweaty, rapid heart beat, trouble breathing/chest pain, horrible cotton mouth, and sweet but vomity taste in my mouth. I almost went to the emergency room, but then it started to lessen. Now I feel so fatigued and my chest hurts. I'm afraid to sleep but I have a biology test at 10am tomorrow. This should be interesting! What are your thoughts on sleeping it off, or should I still contact the hospital?
  13. elleforbes elleforbes

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    • Since: Mar 5, 2007
    • Posts: 10
    Lamictal And Other Drugs Can Be Lethal!

    I recently had a borderline seizure and almost had to be hospitalized because I took lamictal ontop of taking zoloft, ranitidine, and weed. The combination caused my seratonin levels to rise so high that I got a form of drug poisoning calle seratonin syndrome. This syndrome, if the seizure and fever become severe enough, can be fatal!!! 85% of doctors, even psyciatrists, don't know about this syndrome even though it is fairly common. Please read this link if you have had a bad reaction to lamictal and other antidepressants or weed, or any other drug,
    Serotonin Syndrome - A Mix of Medicines That Can Be Lethal - New York Times

    This site will explain the syndrome, list symptoms and give a list of drugs that can cause this syndrome if mixed. Lamictal is a fairly new drug and is not on the list but it is an antipsychotic and people most prone to the syndrome are those who combine an antidepressant with an antipsychotic drug!!!
    Personally, I have never had a problem taking zoloft and smoking weed. It was only until I added lamictal to the equation that I had this reaction. But everyone's body is different, so be careful how you mix your drugs especially when you're dealing with antipsychotics or anticonvulsants!
  14. nerphroll nerphroll

    • Sr. Member
    • Since: Jul 31, 2005
    • Posts: 2,886
    Lamictal is the brand name for lamotrigene.
    Lamotrigene is an antipsychotic and anti-epileptic medication that temporarily modifies several chemical systems in the brain, though precisely how lamotrigene works to treat mental illness or prevent seizures is unknown.
    Even with no other competing medications, simply throw a joint into the mix and anything can happen. It seems that dedbr doesn't have a problem with the drug and weed. Maybe cause he's on a low dose, maybe because he's caffeine and alcohol free, maybe he's just genetically healthier in regards to tolerating the two substances together. Point is, some people are not going to tolerate lamictal with weed, and if you're one of those people, I would either stop completely (first choice) or lower my dose of lamictal and/or cut out other substances, even legal ones.
  15. omgaidiosmio omgaidiosmio

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    • Since: Mar 23, 2007
    • Posts: 2
    hi, like blowingsmoke, i signed up for this site specifically to respond to this thread. a while ago i started taking lamictal (i am now on 100 mg). i had not smoked in a while and when i did (only at 50 mg i believe) i had a terrible reaction. i got mad ripped (really bad ripped) and experienced extreme paranoia and anxiety. my heart was going so fast that i literally thought it might explode haha. it lasted about 5 hours and i was tweaking out the entire time... it sucked. the second time i tried i began feeling the same effects, although i smoked less so they were more less intense. i drove home and almost got in about 500 accidents and passed out right when i got home. so for a while i was really nervous about smoking but decided to try again (like i said i am now on 100 mg of lamictal). i've only smoked bowls and blunts and i take very small hits because i'm very nervous about feeling that way again. i've smoked about five times but haven't gotten too high at all, i start feeling a good high but it goes away five minutes later. how has everyone else ended up?
  16. ludaa ludaa

    • New Member
    • Since: Mar 25, 2007
    • Posts: 2
    Buddah and Lamictal

    I have been on lamictal for about a year now (100 mg) and I have been smoking weed for about 5 years strong. I puff pretty hard. 2 or 3 blunts a day at leaaaaaaast. I have only had about 5 seizures in my life and they were all during periods of me NOT taking my medication. I neglected to take it because sometimes when I wake up I have this ridiculous tension-type headache aaand about 4 hours after I took the pill I would be PASSING OUT tired.. almost for no reason it seems. I'm 20 and I feel like grandpa sometimes lol. I honestly think that smoking marijuana on lamictal is okay, as long as you:
    A) Take your meds!
    B) Don't smoke to pass out. (I usually experience the worst headaches the morning after I smoked late, meaning the nights that I would smoke a fat blunt or two and then immediately go to sleep.)
    C) Try not to wake and bake. (I know it sounds ridiculous, but I sometimes feel more "twitchy" when I smoke early, even when I take my pill.

    If anyone else is also feeling these symptoms of tension headaches or drowsiness, please hollaaa at me. Also, if anyone wants any information on Lamictal (from a pothead/experienced drug user) let me know as well.
  17. newman newman

    • New Member
    • Since: Apr 5, 2007
    • Posts: 2
    New to lamictal and long time occasional smoker

    I have been having some very interesting interactions with Lamictal and weed. I did a google search and found this site. I am very greatful to be able to read other's responses and know that I am not alone. Dx with bipolar at approx. age of 21 years. I suspect I had it much earlier and was "self medicating" as a teenager with weed, alcohol, other drugs to deal the the depression vs mania. I have been on prozac for approx. 14 years now and it has worked well up until the past year. Has anyone heard of SSRI loosing affect after so many years. I'm sure it's a possiblity.

    Anyway, before starting lamictal 5 months ago, I was dealing with a severe bout of depression with my prozac, clonopin for anxiety, depakote for mood and occasional weed (approx. 1-2 bowls per month at the most). I have noticed since smoking while taking lamictal...I cannot sleep! I feel as though time slows down, I don't enjoy the high. I feel heart palpations and anxiety. My mind is in a serious bog that doesn't seem to lift for 2-3 days after smoking. Current dose of lamictal is 200mg...my doc wants me to actually take 50mg in am and 200mg at night. The first six weeks of lacmital minus the weed seemed to "calm me down", and I didn't need the clonopin or weed. After some pretty tramatic crap downloading in my life...I have a chronically ill, trach and g-tube dependant 4 year old (chronically ill since 2 months of age and requires skilled nursing at all times). We have no skilled night nursing, so I am up approx. 3-5 times a night with her. When she is ill, I just sleep on the floor beside her...I guess I am really getting off topic here. Just wanted to give a little insight on my situation.

    I tried smoking salvia and seemed to get a calmer high with that, however so short lived and after smoking it 3 times now over a period of 3 months...it just isn't doing the trick any longer. In fact it is much more expensive than weed.

    So my question...I've been on zoloft, paxil, other SSRI, didn't help out much, so went back to prozac. Anyone else a long term user of prozac here? Also have been on lithium with terrible side effects. Anyone else using antiseizure meds with good results (that do smoke) and do not get the "heebie jeebies" when partaking of an occasional bowl or two?

    Thank you in advance for your replies.
    newman
  18. yellaaa yellaaa

    • New Member
    • Since: Apr 13, 2007
    • Posts: 2
    like a few, i signed up specifically to post on this thread. i'm not a habitual smoker, only do it on random occasions. i'm epileptic and take about 400mg of lamictal a day (can't say i take my prescribed dosage because i rarely do.) a few months ago i was at a concert and smoked beforehand and took a couple of hits prior to the band going on..within 20 minutes or so i had a grand mal seizure (which i've never had before, i've only had simple partial seizures). it was one of the scariest moments of my life, my body was jerking uncontrollably, everything was fuzzy and in slow motion and my body temperature dropped substantially. plus, i missed my favorite band of all time. i went to the hospital and completely bugged out and i vowed never to smoke again. i started taking my meds regularly and noticed that i felt extreme anxiety that increased over time and the same feelings that some have mentioned, especially feeling like i needed to take full deep breaths in order to get oxygen..that feeling completely sucks. a few weeks after the grand mal i decided a joint wouldn't hurt but as a precaution took a pill right before just in case. biggest mistake of my life. i went absolutely insane, my anxiety reached its highest point, i was shivering and shaking and couldn't sit still and i started feeling pins and needles in my right arm..i'm thinking i'm having a stroke, so i proceeded to scratch my arm for 45 minutes straight just to reassure myself that i wasn't having a stroke..afterwards i realized that i scratched so hard i drew blood and cuts but i couldn't even feel that at the time. for the next three weeks i experienced the worst bout of depression you could ever imagine. i hated myself and everyone around me, found zero joy in the things that usually made me happy, i was just completely miserable. i told my neurologist about all of this and he just prescribed me with paxil because this whole anxiety + lamictal thing is, according to him, a complete rarity. i feel completely misunderstood and i just wish that someone would take into consideration the fact that this drug does have a pretty detrimental effect on some people. the anxiety i experience sometimes is horrendous. i'm pushing for a med that suits me better but the doctor won't hear any of it. i thought i'd post this and at the same time thank everyone for posting their experiences as well because it makes me feel like i'm not alone in feeling this way..gahhh =/
  19. Dedbr Dedbr

    • Domestic War Veteran
    • Since: Mar 24, 2001
    • Posts: 21,228
    Couple of things to answer some questions that have been asked......I take 2oo mgs. of Lamictal every day along with 30 mgs. of Cymbalta and 20mgs. of Valium............

    I am an old head who has seen quite a bit, also. :D Like Luda said, I'm willing to help............But let me also say that I am not a doctor, and won't pretend to be. I can speak from experience only.........

    All really serious problems should be taken care of by a doctor........


    Some Where In Ded Land.........
  20. Jason Ray Jason Ray

    • New Member
    • Since: Jun 9, 2007
    • Posts: 2
    Bad Side Effects

    Wow its good to finally hear somebody has had the same side effects as me from Lamictal and Weed. I was recently put on Prozac for a couple months and my dosage went up to 40mg but I started to feel it was waring off so my phyciatrist decided to let me try lamictal so I started it for a week and I had forgot to take it the previous night so I doubled up in the morning to 50mg and took another 20mg of Prozac. A couple hours later I got high for the first time...I was hotboxing in my friends truck and I smoked a few bowls and wasnt high so I smoked another, I got a bad hit because im inexperienced and started coughing and had to drink some water..I went out of my friends truck and went and laid in the back of his truck bed, I was just laying their and I was pretending to be high just for laughs to see what my friends would do...The next thing I know I woke up from a dreamworld and felt really lightheaded and stood up and was like holy shit wtf is going on....I was fucking like hallucinating and shit it was fucking crazy...I thought I was dying, my friends didnt know what to do they thought I was just tripping, It was like living a nightmare where you think your gonna die, everytime I would feel like I was getting better I would close my eyes and my mind would reset and the nightmare would restart I had to laydown my head was spinning n shit...My friends thought I was just not used to being high so they were trying to calm me down...It wasnt possible, I passed out a few times and my friends didnt know what to do...I just went to my friends house for a few hours and eventually the nightmare ended...It was probably one of the worst highes anyone has every seen...If your blazing someone out for the first time I advise you make sure there not taking anti-depressents....I wanna keep blazing it but i dont know what to do...If anyone has any Ideas please reply.

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