US: Marijuana's Key Ingredient May Fight Alzheimer's Disease

Discussion in 'The Drug War Headline News' started by claygooding, Oct 12, 2011.

  1. claygooding claygooding

    • DrugWarVeteran
    • Since: May 13, 2009
    • Posts: 9,611
    US: Marijuana's Key Ingredient May Fight Alzheimer's Disease
    FoxNews
    / Charles Q Choi / 10,11,2011

    [IMG]
    AP

    AChE is known to help accelerate the formation of abnormal protein clumps in the brain, known as amyloid plaques, during Alzheimer's. The active ingredient of marijuana could be considerably better at suppressing the abnormal clumping of malformed proteins that is a hallmark of Alzheimer's disease than any currently approved prescription drugs.

    Scientists report the finding in the Oct. 2 issue of the journal Molecular Pharmaceutics.

    About 4.5 million Americans suffer from
    Alzheimer's disease, which gradually destroys memory. As more people survive into old age, cases of Alzheimer’s disease are expected to triple over the next 50 years. There is no known cure.

    The researchers looked at THC, the compound inside marijuana responsible for its action on the brain.

    Computer models suggested THC might inhibit an enzyme with the tongue-twisting name of acetylcholinesterase (also called AChE) that is linked to Alzheimer's.

    This enzyme also helps break down the brain chemical
    acetylcholine, which is linked to memory and learning. Acetylcholine levels are reduced during Alzheimer's.

    In lab experiments, the scientists found THC was significantly better at disrupting the abnormal clumping of malformed proteins.


    THC could completely prevent AChE from forming
    amyloid , while two drugs approved for use against Alzheimer's, donepezil and tacrine, reduced clumping by only 22 and 7 percent, respectively, at twice the concentration of THC used in the tests.

    "We're not advocating smoking dope, but if we can make analogues of THC, it could play a role in
    treating ," researcher Kim Janda, a chemist at the Scripps Research Institute in La Jolla, Calif., told LiveScience. "It would be nice to do more animal studies along these lines."

    Past research on human brain tissues and experiments with rats have suggested that synthetic analogues of THC can reduce the inflammation and prevent the mental decline associated with Alzheimer's .

    However, marijuana is not necessarily good for the mind.

    Prior investigations have shown that years of heavy marijuana use, consisting of four or more joints a week, can impair memory, decision-making and the ability to pay attention to more than one thing at a time.



    All investigations that show harm in marijuana are paid for by NIDA and the ONDCP and where does science stop and drug policy begin?
    I underlined where drug policy began and science stopped in this article.


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  2. Dedbr Dedbr

    • Domestic War Veteran
    • Since: Mar 24, 2001
    • Posts: 21,228
    Why clay? Why do we continue to find stories that speak of the efficacy of herb in these terrible diseases that plague man, and we hear this.......
    Animal studies? Animal studies. What the hell they think we are.....:thumb:

    If they're that sure it works, what the hell they gonna do, wait and do tests while folks slowly die painful deaths instead of beating this terrible disease, and yeah let them smoke dope! :hat:

    If they think it's going to hurt them, it's not. This hurts them.....

    Why, oh why, do they have to pull the stupid OLD stoner out of the bag every time? The real question is, wouldn't anybody prefer to be memory impaired and to impair the decision making part of your brain and the ability to pay attention to more than one thing at a time than to be in the Dead Zone of Alzheimer's?

    Ya know what? These folks are really idiots........:rolleyes:


    Ded.....
  3. claygooding claygooding

    • DrugWarVeteran
    • Since: May 13, 2009
    • Posts: 9,611
    The paragraph is the required disclaimer on any findings of medical efficacy of marijuana,,required if the researcher ever wants to do any research with govt funding.
    1 people like this.
  4. gristlehead gristlehead

    • New Member
    • Since: Jan 4, 2010
    • Posts: 4

    Past research on human brain tissues and experiments with rats have suggested that synthetic analogues of THC can reduce the inflammation and prevent the mental decline associated with Alzheimer's .


    I love how it always boils down to this. Rather than using the natural form, we must instead make a "synthetic analogue" so we can patent this shit. Then, and only then, can we make money, therefore making said drug good for you. Get a grip, pharma companies. We're tired of your synthetic crap. Give us some good, natural medicine for a change.

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