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Old 05-29-2005, 07:01 PM   #1
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Default Marinol

Are there any drug tests that can tell the difference between Marinol and smoking marijuana? Does synthetic THC look the same as smoking marijuana on the test?

Is there any way to tell the difference? Specific tests or different test for people with a legal prescription
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Old 05-29-2005, 07:30 PM   #2
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Our staff chemist ( ) tells us that the difference can be detected in a GC/MS test but not an EMIT.
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Old 05-31-2005, 12:35 AM   #3
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Buzzby,
That is correct sir...!! I researched this extensively, and found that there is a small chemical difference between ingestion of marijuana, and ingestion of Marinol.... Both will show positive on the initial screen, but can be decifered with the dreaded GC test.
Did you just say that???
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Old 05-31-2005, 01:03 AM   #4
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Quote:
Originally Posted by Wizard1
Buzzby,
That is correct sir...!! I researched this extensively, and found that there is a small chemical difference between ingestion of marijuana, and ingestion of Marinol.... Both will show positive on the initial screen, but can be decifered with the dreaded GC test.
Did you just say that???
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Wiz
Yes he said that. Marinol contains a single cannabinoid molecule (THC). Weeds contain lots of different cannabinoid molecules. When a GC/MS is run each molecule will show its own profile.
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Old 05-31-2005, 01:27 PM   #5
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Quote:
Originally Posted by Wizard1
Did you just say that???
I think you just tested positive for short term memory loss...


Quote:
Originally Posted by didorusso
Marinol contains a single cannabinoid molecule (THC). Weeds contain lots of different cannabinoid molecules. When a GC/MS is run each molecule will show its own profile.
My understanding is that the active chemical in Marinol (Dronabinol) is a synthetic variant of THC and shows up separately on a GC/MS.
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Old 05-31-2005, 01:53 PM   #6
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Quote:
My understanding is that the active chemical in Marinol (Dronabinol) is a synthetic variant of THC and shows up separately on a GC/MS
Bingo ...

So if say someone were going to claim "false positive" because they had been prescribed marinol -- think it through again...

Not to mention a Marinol is a difficult script to obtain

Is costly on the legal market (about $15 a pill) -- so very costly on the black market...

And consider this: That black market Marinol you purchase means that some suffering AIDS Patient, Cancer Patient or other seriously ill individual is being denied their medicine... And that is just plain Bad Karma...
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Old 05-31-2005, 02:02 PM   #7
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Quote:
Originally Posted by Mamabudz
And consider this: That black market Marinol you purchase means that some suffering AIDS Patient, Cancer Patient or other seriously ill individual is being denied their medicine... And that is just plain Bad Karma...
And for every glass of water I drink, some poor child in Sub-saharan Africa is dying of thirst...

The logical supposition would be that they'll make some more to compensate for losses in channels. That's what they do for every other drug that finds its way into the black market. Drugstores aren't running out of Oxycontin...
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Old 05-31-2005, 02:47 PM   #8
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Quote:
Originally Posted by Buzzby
My understanding is that the active chemical in Marinol (Dronabinol) is a synthetic variant of THC and shows up separately on a GC/MS.
Correct. I am positive that it is synthetic molecule, not sure if it can be called a variant. Aren't the two molecules (natural and synthetic) identical? If you don't know I will have to look up.
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Old 05-31-2005, 03:03 PM   #9
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Yup, they're identical.

http://www.ncbi.nlm.nih.gov/entrez/q...601&query_hl=1

They look for other metabolites in the urine sample that wouldn't be found from Marinol use, but in marijuana usage.
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Old 05-31-2005, 06:03 PM   #10
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That study shows that with GC/MS testing it is possable to distinguise between THC-COOH and THCV-COOH. But I don't see anything about testing standards being changed. If I go in for my annual DOT UA, and had a script for Marinol, is MedTox going to run a second GC/MS to determin the presents, or lack of, of THCV-COOH, to determin if marijuana has been consumed along with Marinol, and if so, is that allowed under DOT/SAMHSA guidelines to test for THCV-COOH? I was just looking and could not find any regs for DOT or SAMHSA specifying what specific metabolite(s) is/are to be tested for with the GC/MS conformation for THC. Is THC-COOH listed somewhere in a gov reg as the only metabolite used to confirm, or is it just the metabolite the labs chose? N2
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