S2

For some reason, aspirin triggers a false negative on the common Assay-type urine screens. Myself and some others have been successful using a combination of dilution and aspirin to beat the drug test. this post will describe the method I use and I will leave it open for as long as it takes to work out some questions that may come up, then I will close it and make it sticky as a reference so that the specific method is easliy located.
Here's what I have done:

I don't dilute with water, I dilute with gatorade or pedialyte to which I add about 2 tablespoons of salt per quart (it tastes pretty bad)

I also take a half dozen Tums or rolaids

The reason I do the above is to consume extra salts and minerals in the hopes that as I dilute my urine I am keeping my specific gravity up in case it is checked-- a low specific gravity, which will occur if you flush you system with excess water and it is a means of detecting dilution.

I always go to the lab within minutes of it opening-- i do this because there is usually only one or two people working right at the opening and they have to multi task getting the place open and dealing with their first cup of coffe and chit chat etc and they may be more likely to skip checking temps specific gravity etc.

I always wear a suit and tie (I'm in my mid forties and want to appear to be mainstream, not alternate lifestyle)


I take a creatine supplement bginnning two days prior and up to test time--creatine does not build up in yor system very much so it doesnt make sense to increase it for much more than a day or so prior.


Test day.

2 hours prior to test I get up and urinate then drink:

1 quart of liquid, creatine supp. 3 aspirin, 4 rolaids

1hour prior

1 quart of liquid, 3 aspirin, b vitamin, 4 rolaids

1/2 hour prior

2 quarts liquid, 2 aspirin, 4 rolaids


I uriniate as I feel the need throughout the process and right up to test time, there is no worry about being able to produce a sample, trust me your problem is going to be getting there without going in the car!

I suggest that you test the process with water vitamin alone sometime prior to test day to determine at what point it is best to take the aspirin. Take it too late and it doesnt have time to show up. Take it too early and it flushes out before your test.

Color is probably the least thing to worry about though givin thatmost people that drink a healthy amount of water have pretty clear urine.

Well that's it. That has worked for me three times now.

I am also a proponent of using home tests and doing dry runs to gain confidence that I am timing thing correctly and that it will work--nothing like that negative home test to eliminate some of the jitters.

teufelfisch

Could aspirin cause a false negative because it oxidizes the THC metabolite?

The active component of aspirin is salicylic acid. This is what the Native Americans got out of willow bark when they chewed it. However, it wreaks havoc on the somach so somebody figured out that it can be esterized with acetic acid, and made into aspirin. It's still the salicylic acid that gets absorbed into your bloodstream - maybe it burns off the THC metabolite in your blood, causing a false negative until more is released by your fat cells.

If somebody could find a transport mechanism to get the salicylic acid to your fat cells, it might effectively remove all THC metabolite from your body - a *true* detox!

That is, of course, assuming what I done thunk up about aspirin is right. Pretty big assumption.

Great advice, S2!

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S2

tuefelfisch, most likely aspirin reacts chmically with the assay material itself and causes the red line to stain--- bear in mind that urine tests are NOT looking for THC, it is the metabolites of THC that are scanned since THC is broken down quite quickly by the body-- frankly a THC test would be much more appropriate since it measures recent use and the current system measures use up to 30 days in the past-- I can understand an employer demanding that an employee not working under the infuence but it is ridiculous that they are essentially barring employment of people who simply use marijuana on their own time.


NOTE: please restrict posts in this thread to questions directly related to the dilution /aspirin technique, (yours was tuefel)

Questions pertaining to your specific situation should get their own thread.

WorriedCitizen

does the aspirin technique work on all tests... includin tha cup test?

S2

the ones I could find on line looked like they were all assay type test and therefore this should work--frankly dilution alone shoudl work, the aspirirn is just added insurance.

Smokalicious

by dilution do you just mean drinking a lot of water?

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S2

yes

S2

Decreased signal in Emit assays of drugs of abuse in urine after ingestion of aspirin: potential for false-negative results.

Wagener RE, Linder MW, Valdes R Jr.

Department of Pathology, University of Louisville School of Medicine, University of Louisville Hospital, KY 40292.

During routine drug analysis with the Syva d.a.u. Emit immunoassays we observed a high frequency of urines with lower rates of changes in absorbance (delta A R) than the rate for a drug-free urine calibrator. Many of these urines contained salicylates. Among 40 urines with apparent salicylate concentrations between 15 and 420 mg/dL tested for benzoylecgonine (BE), 20 had delta A R < -4 (range +2 to -28 mA/min). The rates decreased with increasing salicylate: delta A R = -0.057 x (salicylate, mg/dL) -0.22 mA/min (r = 0.85, n = 40, P < 0.01). Urines from 100 control subjects (no salicylate) had mean +/- SD delta A R values of -1.05 +/- 2.2 mA/min (range +3 to -7; only two were < -4 mA/min). Although direct addition of salicylic acid (200 mg/dL) to urine specimens did not reproduce the negative bias, ingestion of aspirin (acetylsalicylic acid) did by -0.09 mA/min per 1 mg/dL (72.4 mumol/L) salicylate. Negative biases observed for other Emit d.a.u. assays after salicylate ingestion lead us to conclude that ingestion of therapeutic doses of aspirin may cause false-negative results for drug screens in urines by this technology.

PMID: 8149618 [PubMed - indexed for MEDLINE]

S2

cant quite figure our their absorbtion units but what this says to me is that the samples containing aspririn do trigger false negative but they also behave differently than a "normal" clean sample i.e.' : "...lower rates of changes in absorbance (delta A R) than the rate for a drug-free urine calibrator..."

This means that there may be a method of detecting the aspirin adulteration down the road-- this is what I am on the look out for.

S2

The rolaids and the salt and gatorade are to try to keep the specific gravity up-- drinking pure h20 definitely lowers SG, dont know if the salt/calcium does but I figure it cant hurt