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Bilbo3452 · 05-18-2008, 06:07 PM

When a lab tests for the validity of a sample, do they test for the creatinine level first and only if that is too low do they test for the specific gravity? or are both check? Do both of the levels have to be under the lower threshold for the sample to be dilute, or will only one being too low cause a negative dilute? Thanks for your reply.

**Sec** · 05-18-2008, 06:31 PM

§ 40.89 What is validity testing, and are laboratories required to conduct it?
(a) Specimen validity testing is the evaluation of the specimen to determine if it is consistent with normal human urine. The purpose of validity testing is to determine whether certain adulterants or foreign substances were added to the urine, if the urine was diluted, or if the specimen was substituted.
(b) As a laboratory, you are authorized to conduct validity testing.
[65 FR 79526, Dec. 19, 2000, as amended at 66 FR 41951, Aug. 9, 2001]

§ 40.91 What validity tests must laboratories conduct on primary specimens?
As a laboratory, when you conduct validity testing under §40.89, you must conduct it in accordance with the requirements of this section.
(a) You must determine the creatinine concentration on each primary specimen. You must also determine its specific gravity if you find the creatinine concentration to be less than 20 mg/dL.
(b) You must determine the pH of each primary specimen.
(c) You must perform one or more validity tests for oxidizing adulterants on each primary specimen.
(d) You must perform additional validity tests on the primary specimen when the following conditions are observed:
(1) Abnormal physical characteristics;
(2) Reactions or responses characteristic of an adulterant obtained during initial or confirmatory drug tests (e.g., non-recovery of internal standards, unusual response); or
(3) Possible unidentified interfering substance or adulterant.
(e) If you determine that the specimen is invalid and HHS guidelines direct you to contact the MRO, you must contact the MRO and together decide if testing the primary specimen by another HHS certified laboratory would be useful in being able to report a positive or adulterated test result.
[65 FR 79526, Dec. 19, 2000, as amended at 69 FR 64867, Nov.9, 2004]

§ 40.93 What criteria do laboratories use to establish that a specimen is dilute or substituted?
(a) As a laboratory you must consider the primary specimen to be dilute when:
(1) The creatinine concentration is greater than or equal to 2mg/dL but less than 20 mg/dL, and
(2) The specific gravity is greater than 1.0010 but less than 1.0030 on a single aliquot.
(b) As a laboratory you must consider the primary specimen to be substituted when the creatinine concentration is less than 2 mg/dL and the specific gravity is less than or equal to 1.0010 or greater than or equal to 1.0200 on both the initial and confirmatory creatinine tests and on both the initial and confirmatory specific gravity tests on two separate aliquots.
[65 FR 79526, Dec. 19, 2000, as amended at 69 FR 64867, Nov.9, 2004]

§ 40.95 What criteria do laboratories use to establish that a specimen is adulterated?
(a) As a laboratory, you must consider the primary specimen to be adulterated if you determine that—
(1) A substance that is not expected to be present in human urine is identified in the specimen;
(2) A substance that is expected to be present in human urine is identified at a concentration so high that it is not consistent with human urine; or
(3) The physical characteristics of the specimen are outside the normal expected range for human urine.
(b) In making your determination under paragraph (a) of this section, you must apply the criteria in current HHS requirements or specimen validity guidance.

Bilbo3452 · 05-18-2008, 07:43 PM

Thanks Sec for replying even though you probably have answered that question a million times before. Correct me if I'm wrong. Sg is only checked once creatinine levels are determined to be low. And a sample will be dilute if both the creatinine levels and sg are too low.

**Sec** · 05-18-2008, 08:20 PM

I can find nothing on the reports that I get indicating level of specific gravity for any tst with a creatinine level greater than 20. I do see specific gravity levels showing on lab reports for creatinine levels less than 20, however.

Bilbo3452 · 05-18-2008, 08:59 PM

Quote:

Originally Posted by Sec

I can find nothing on the reports that I get indicating level of specific gravity for any tst with a creatinine level greater than 20. I do see specific gravity levels showing on lab reports for creatinine levels less than 20, however.

Interesting.... So it would seem that taking creatine is more important than trying to raise your specific gravity.

05-18-2008, 06:07 PM	#1
Bilbo3452 New Member Join Date: May 2007 Posts: 17 Grams: 937.50 Groans: 0 Groaned at 0 Times in 0 Posts Thanks: 1 Thanked 0 Times in 0 Posts Stock Portfolio Total Value: 0.000 Gain/Loss: 0.000%	Dilution Question When a lab tests for the validity of a sample, do they test for the creatinine level first and only if that is too low do they test for the specific gravity? or are both check? Do both of the levels have to be under the lower threshold for the sample to be dilute, or will only one being too low cause a negative dilute? Thanks for your reply.

05-18-2008, 06:31 PM	#2
Sec Super Moderator Join Date: Dec 2005 Posts: 6,377 Grams: 42,654.23 Groans: 16 Groaned at 30 Times in 25 Posts Thanks: 698 Thanked 1,574 Times in 972 Posts Stock Portfolio Total Value: 0.000 Gain/Loss: 0.000%	§ 40.89 What is validity testing, and are laboratories required to conduct it? (a) Specimen validity testing is the evaluation of the specimen to determine if it is consistent with normal human urine. The purpose of validity testing is to determine whether certain adulterants or foreign substances were added to the urine, if the urine was diluted, or if the specimen was substituted. (b) As a laboratory, you are authorized to conduct validity testing. [65 FR 79526, Dec. 19, 2000, as amended at 66 FR 41951, Aug. 9, 2001] § 40.91 What validity tests must laboratories conduct on primary specimens? As a laboratory, when you conduct validity testing under §40.89, you must conduct it in accordance with the requirements of this section. (a) You must determine the creatinine concentration on each primary specimen. You must also determine its specific gravity if you find the creatinine concentration to be less than 20 mg/dL. (b) You must determine the pH of each primary specimen. (c) You must perform one or more validity tests for oxidizing adulterants on each primary specimen. (d) You must perform additional validity tests on the primary specimen when the following conditions are observed: (1) Abnormal physical characteristics; (2) Reactions or responses characteristic of an adulterant obtained during initial or confirmatory drug tests (e.g., non-recovery of internal standards, unusual response); or (3) Possible unidentified interfering substance or adulterant. (e) If you determine that the specimen is invalid and HHS guidelines direct you to contact the MRO, you must contact the MRO and together decide if testing the primary specimen by another HHS certified laboratory would be useful in being able to report a positive or adulterated test result. [65 FR 79526, Dec. 19, 2000, as amended at 69 FR 64867, Nov.9, 2004] § 40.93 What criteria do laboratories use to establish that a specimen is dilute or substituted? (a) As a laboratory you must consider the primary specimen to be dilute when: (1) The creatinine concentration is greater than or equal to 2mg/dL but less than 20 mg/dL, and (2) The specific gravity is greater than 1.0010 but less than 1.0030 on a single aliquot. (b) As a laboratory you must consider the primary specimen to be substituted when the creatinine concentration is less than 2 mg/dL and the specific gravity is less than or equal to 1.0010 or greater than or equal to 1.0200 on both the initial and confirmatory creatinine tests and on both the initial and confirmatory specific gravity tests on two separate aliquots. [65 FR 79526, Dec. 19, 2000, as amended at 69 FR 64867, Nov.9, 2004] § 40.95 What criteria do laboratories use to establish that a specimen is adulterated? (a) As a laboratory, you must consider the primary specimen to be adulterated if you determine that— (1) A substance that is not expected to be present in human urine is identified in the specimen; (2) A substance that is expected to be present in human urine is identified at a concentration so high that it is not consistent with human urine; or (3) The physical characteristics of the specimen are outside the normal expected range for human urine. (b) In making your determination under paragraph (a) of this section, you must apply the criteria in current HHS requirements or specimen validity guidance. __________________ Guidelines. Search http://www.marijuana.com/drug-test/index

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05-18-2008, 07:43 PM	#3
Bilbo3452 New Member Join Date: May 2007 Posts: 17 Grams: 937.50 Groans: 0 Groaned at 0 Times in 0 Posts Thanks: 1 Thanked 0 Times in 0 Posts Stock Portfolio Total Value: 0.000 Gain/Loss: 0.000%	Thanks Sec for replying even though you probably have answered that question a million times before. Correct me if I'm wrong. Sg is only checked once creatinine levels are determined to be low. And a sample will be dilute if both the creatinine levels and sg are too low.

05-18-2008, 08:20 PM	#4
Sec Super Moderator Join Date: Dec 2005 Posts: 6,377 Grams: 42,654.23 Groans: 16 Groaned at 30 Times in 25 Posts Thanks: 698 Thanked 1,574 Times in 972 Posts Stock Portfolio Total Value: 0.000 Gain/Loss: 0.000%	I can find nothing on the reports that I get indicating level of specific gravity for any tst with a creatinine level greater than 20. I do see specific gravity levels showing on lab reports for creatinine levels less than 20, however.

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