New Study: Δ9-THCA Has Potent Neuroprotective Properties


THCA (Δ9-tetrahydrocannabinol), the most abundant non-psychoactive cannabinoid found in marijuana, has demonstrated its potent neuroprotective ability in a recent study.

Published in the British Journal of Pharmacology, the Spanish study conducted at Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), in Córdoba, Spain, found Δ9-THCA is a worthy treatment option for those suffering from debilitating neurodegenerative diseases.

Neurodegenerative Disorders and Δ9-THCA


According to the National Institutes of Health, neurodegenerative and neuroinflammatory diseases “result from the gradual and progressive loss of neural cells, leading to nervous system dysfunction.”

Unfortunately, these diseases affect more than 50 million Americans annually.

For the THCA study, “In vivo neuroprotective activity of Δ9-THCA was investigated in mice intoxicated with the mitochondrial toxin 3-nitropropionic acid (3-NP).”

The results of the study found “Cannabinoid acids bind and activate PPARγ with higher potency than their decarboxylated products. Δ9-THCA increases mitochondrial mass in neuroblastoma N2a cells, and prevents cytotoxicity induced by serum deprivation. Δ9-THCA, through a PPARγ-dependent pathway, was neuroprotectant in mice intoxicated with 3-NP, improving motor deficits and preventing striatal degeneration.”

The study concluded: “Δ9-THCA shows potent neuroprotective activity, worth consideration for the treatment of Huntington’s Disease and possibly other neurodegenerative and neuroinflammatory diseases. “

An effectual neuroprotectant, Δ9-THCA could be beneficial in the treatment multiple sclerosis, Alzheimer’s, and Parkinson’s disease.

About Author

Born in Long Beach, raised on the central coast: I surf, dab, burn, and blog – though not necessarily in that order. I'm a husband, a father and a lifelong consumer of connoisseur grade weed. I don't drink alcohol or consume any other "drugs." I consider myself to be living proof that weed is not a gateway drug. If it were, I'd be in some serious trouble. Instead, as a 50-year-old ex-realtor that has been smoking weed for nearly 80% of my life (just did the math) ... I can only say, marijuana is safer than prescription pills or alcohol could ever hope to be for calming what stirs the savage beast.


    • George Alexander on

      I have your back on that one !!! Smokers will for sure be more healthy than others that self medicate with other substances

  1. Mike L. Wallace Jr. on

    The creation of Marijuana Prohibition deprived our bodies important Endocannabinoid Systems of necessary Cannabinoids. Which threw our bodies Homeostasis Out of Whack & created many illnesses. Now after many Generations of Cannabinoid Deficient parents later. Children are being born with & early developing Horrible illnesses , Mental Health Conditions & Cancers. It would not be a stretch to say that most illnesses of today Relieved by Marijuana are caused by Cannabinoid Deficiencies. Marijuana needs to be Legalized Nationwide. To Relieve the Suffering , Save Lives & take a massive burden off of Healthcare. But Congress has long chosen to drag their feet on the issue or promote Medical Marijuana. Medical Marijuana requires we develop illnesses (Like Cancerous Tumors) RISKING DEATH. Before going to a Doctor to try to get a Prescription. Marijuana needs to be Legal like Recreational Marijuana access. Which Fights illnesses , Prevents illnesses & Protects Future Generations from Birth Defects & Early Life illnesses. When America becomes a Happy Healthy Healing Society I hope we look back & punish the War Criminals Jeff Sessions , Chris Christie , Nora Volkow , The DEA & Members of SAM. Who Deliberately allowed Adults , Seniors & Children to Horrible Suffer & / or Die.

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